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Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29578, updated on 18-Sep-2024

Summary

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Official Symbol
Hnrnpa1provided by RGD
Official Full Name
heterogeneous nuclear ribonucleoprotein A1provided by RGD
Primary source
RGD:69234
See related
EnsemblRapid:ENSRNOG00000036839 AllianceGenome:RGD:69234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnrpa1; hnRNP A1
Summary
Enables nucleic acid binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to thapsigargin; and cellular response to tunicamycin. Located in cytosol and nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 954.1), Spleen (RPKM 755.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hnrnpa1 in Genome Data Viewer
Location:
7q36
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136253633..136260085)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134375318..134381610)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144865302..144871592)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093746 Neighboring gene uncharacterized LOC103692988 Neighboring gene single-strand-selective monofunctional uracil-DNA glycosylase 1 Neighboring gene chromobox 5 Neighboring gene nuclear factor, erythroid 2 Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene microRNA 148b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exon silencing by UAGG motifs in response to neuronal excitation. An P, et al. PLoS Biol, 2007 Feb. PMID 17298175, Free PMC Article
  2. Molecular mimicry: cross-reactive antibodies from patients with immune-mediated neurologic disease inhibit neuronal firing. Kalume F, et al. J Neurosci Res, 2004 Jul 1. PMID 15197740
  3. Autoimmunity due to molecular mimicry as a cause of neurological disease. Levin MC, et al. Nat Med, 2002 May. PMID 11984596, Free PMC Article
  4. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. Hanamura A, et al. RNA, 1998 Apr. PMID 9630249, Free PMC Article
  5. Expression and cDNA sequence of helix destabilizing protein (HDP) in rat lung. Rayani HH, et al. Exp Lung Res, 1998 Jan-Feb. PMID 9457472

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.
    Title: Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.
  2. Data indicate that heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) participates in the IRES (internal ribosome entry site) -dependent translation of sterol-regulatory-element-binding protein 1 (SREBP-1a) mRNA through RNA-protein interaction.
    Title: hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress.
  3. data show that hnRNP A1 is an important Quaking target that contributes to its control of myelin gene expression
    Title: Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA/DNA annealing activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables RNA strand annealing activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables single-stranded DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomeric repeat-containing RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within RNA splicing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to epidermal growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to potassium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to sodium arsenite ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to sodium arsenite ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lung development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear export ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasmic periphery of the nuclear pore complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in organelle IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein A1
Names
HDP
helix-destabilizing protein
hnRNP core protein A1
single-strand RNA-binding protein

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399274.1 → NP_001386203.1  heterogeneous nuclear ribonucleoprotein A1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P04256
    UniProtKB/TrEMBL
    A0A8I6ALC1, A6KD00
    Related
    ENSRNOP00000074880.3, ENSRNOT00000091596.3
    Conserved Domains (3) summary
    pfam11627
    Location:308 → 345
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:105 → 184
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12761
    Location:12 → 92
    RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

  2. NM_017248.3 → NP_058944.2  heterogeneous nuclear ribonucleoprotein A1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P04256
    UniProtKB/TrEMBL
    F7FEZ6, Q5I0M7
    Related
    ENSRNOP00000052160.6, ENSRNOT00000055285.6
    Conserved Domains (3) summary
    pfam11627
    Location:255 → 292
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:105 → 184
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12761
    Location:12 → 92
    RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    136253633..136260085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263120.1 → XP_063119190.1  heterogeneous nuclear ribonucleoprotein A1 isoform X1

    UniProtKB/Swiss-Prot
    P04256
    UniProtKB/TrEMBL
    A0A8I6ALC1, A6KD00

  2. XM_063263121.1 → XP_063119191.1  heterogeneous nuclear ribonucleoprotein A1 isoform X2

    UniProtKB/Swiss-Prot
    P04256
    UniProtKB/TrEMBL
    F7FEZ6, Q5I0M7
    Related
    ENSRNOP00000094714.2, ENSRNOT00000113929.2

RNA

  1. XR_010052947.1 RNA Sequence

    Related
    ENSRNOT00000154593.1

  2. XR_356017.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04256.3 GenPept UniProtKB/Swiss-Prot:P04256

Gene LinkOut

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